AbstractDoxorubicin (DOX), a commonly used anti-cancer drug, is limited by its cardiotoxicity and multidrug resistance (MDR) of tumor cells.Epigallocatechin gallate (EGCG), a natural antioxidant component, can effectively reduce the cardiotoxicity of DOX.Meanwhile, EGCG can inhibit the expression of P-glycoprotein (P-gp) and reverse the MDR of tumo
Network compression as a quality measure for protein interaction networks.
With the advent of large-scale protein interaction studies, there is much debate about data quality.Can different noise levels in the measurements be assessed by analyzing network structure? Because proteomic regulation is inherently co-operative, modular and redundant, it is inherently compressible when represented as a network.Here we propose tha
Explicit ion modeling predicts physicochemical interactions for chromatin organization
Molecular mechanisms that dictate chromatin organization in vivo are under active investigation, and the extent to which intrinsic interactions contribute to this process remains debatable.A central quantity for evaluating their contribution is the strength of nucleosome-nucleosome binding, which previous experiments have estimated to range from 2
Late Triassic sauropodomorph and Middle Jurassic theropod tracks from the Xichang Basin, Sichuan Province, southwestern China: First report of the ichnogenus Carmelopodus
Upper Triassic and Middle Jurassic strata of the Xichang Basin in Sichuan Evaporator with Defrost Element Province, southwestern China, yielded important dinosaur ichnofossils.From the Xujiahe Formation of the Yiguojiao tracksite, we report a Late Triassic footprint assemblage in China and the first discovery of diagnostic Triassic sauropodomorph t